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High levels of glucocorticoids make neurons across the brain more susceptible to oxidative insults via well-described actions of glucocorticoids, including downregulating several antioxidant enzymes and increasing baseline levels of ROS production (ahin and Gml, 2004

Bill MA, Nicholas C, Mace TA, Etter JP, Li C, Schwartz EB, et al

The majority of these studies have been conducted in mice, including transgenic models of AD (APP/PSI, 3xTg-AD, SAMP8, 5XFAD, and APP knock-in mice), mice in which AD-like symptoms have been induced by the injection of a specific substance (beta amyloid peptides, D-galactose, or scopolamine), and aged mice

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Zdrowe komrki maj tylko 1% glutationu nieaktywnego

10.1016/j.chembiol.2020.02.005 96 LiuP.FengY.LiH.ChenX.WangG.XuS.et al (2020b)